Is MOTS-c FDA-approved?

No. MOTS-c is not approved for clinical use by the FDA, MHRA, Health Canada, or the TGA. Research-peptide vendors sell it for laboratory research only.

What is the half-life of MOTS-c?

Published rodent studies report a circulating half-life of roughly 1–2 hours, with exercise-induced peaks returning to baseline within about 4 hours after activity.

What dose of MOTS-c is used in research?

Doses reported in published preclinical studies vary substantially by species, route, and metabolic endpoint. Pepticker does not publish a dosing protocol — refer to the original study you are reproducing.

Is MOTS-c the same as a GLP-1 agonist?

No. MOTS-c is a mitochondrial-derived peptide that signals through pathways distinct from the GLP-1 axis. It is positioned in research as an exercise-mimetic rather than as a GLP-1-class metabolic compound.

MOTS-c is sold for research use in the US, Canada, and the UK. In Australia it is TGA Schedule 4 and personal import is tightly controlled. Status is informational — not legal advice.

longevity

MOTS-c

Mitochondrial exerkine

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About

A 16-residue peptide encoded within the mitochondrial 12S rRNA. Studied as an exercise-mimetic exerkine for metabolic health and longevity.

Also known as: Mitochondrial-derived peptide

Reconstitution calculator

For research purposes only. Not for human consumption. Always verify calculations independently.

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§ Frequently asked

Common questions about MOTS-c

What is MOTS-c?: MOTS-c is a 16-residue peptide encoded within the mitochondrial 12S rRNA gene. It is studied as an exercise-mimetic exerkine for metabolic health, insulin sensitivity, and longevity-relevant endpoints in preclinical research.
Is MOTS-c FDA-approved?: No. MOTS-c is not approved for clinical use by the FDA, MHRA, Health Canada, or the TGA. Research-peptide vendors sell it for laboratory research only.
What is the half-life of MOTS-c?: Published rodent studies report a circulating half-life of roughly 1–2 hours, with exercise-induced peaks returning to baseline within about 4 hours after activity.
What dose of MOTS-c is used in research?: Doses reported in published preclinical studies vary substantially by species, route, and metabolic endpoint. Pepticker does not publish a dosing protocol — refer to the original study you are reproducing.
Is MOTS-c the same as a GLP-1 agonist?: No. MOTS-c is a mitochondrial-derived peptide that signals through pathways distinct from the GLP-1 axis. It is positioned in research as an exercise-mimetic rather than as a GLP-1-class metabolic compound.
Is MOTS-c legal?: MOTS-c is sold for research use in the US, Canada, and the UK. In Australia it is TGA Schedule 4 and personal import is tightly controlled. Status is informational — not legal advice.

Editorial summary of published research. Not medical advice. See /methodology for sourcing.

Research use only. The compounds listed on this page are not approved for human use through research-chemical channels. Nothing on this page is medical advice. Consult a qualified clinician before considering any peptide protocol. See affiliate disclosure and our scoring methodology.

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