Ipamorelin is a synthetic pentapeptide ghrelin-receptor agonist that selectively stimulates GH release without the substantial cortisol or prolactin elevations associated with older ghrelin-mimetic compounds like GHRP-2 and GHRP-6.

Is ipamorelin FDA-approved?

No. Ipamorelin is not approved by the FDA, MHRA, Health Canada, or the TGA for any indication. Research-peptide vendors sell it for laboratory research only.

What is the half-life of ipamorelin?

Published pharmacokinetic studies report a half-life of approximately 2 hours after subcutaneous administration, which supports the multi-times-per-day dosing patterns used in published research protocols.

What dose of ipamorelin is used in research?

Doses reported in published preclinical and early human studies vary by endpoint. Pepticker does not publish a dosing protocol — refer to the original literature for the specific study you are reproducing.

What is ipamorelin commonly stacked with?

The most widely discussed stack is ipamorelin plus CJC-1295 (with or without DAC) — pairing the ghrelin-arm and GHRH-arm of GH secretion in research protocols.

Ipamorelin is sold for research use in the US, Canada, and the UK. In Australia it is TGA Schedule 4 and personal import is tightly controlled. Status is informational — not legal advice.

gh secretagogue

Ipamorelin

Selective GH secretagogue

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About

A pentapeptide ghrelin-receptor agonist that selectively stimulates GH release without significant cortisol or prolactin increase.

Also known as: IPAM, ipa, Ipa, IPA, OmA – Ipamorelin, OmA – Ipa

Commonly cited research dose ranges

Not medical advice. These are ranges reported in research literature, not personalized recommendations. Consult your physician.

Range30 – 100 mcg

Study type: Phase 2 randomized controlled trial in bowel-resection patients, and human pharmacokinetic dose-escalation studies.

Literature notes: Literature reports intravenous infusion twice daily in the postoperative ileus trial and single subcutaneous doses in pharmacokinetic studies.

Citations

Popescu et al., Int J Colorectal Dis, 2014
“Ipamorelin twice daily intravenously for up to 7 days was well tolerated in the phase 2 postoperative ileus cohort.”
Hansen et al., Pharm Res, 1999
“The pharmacokinetic parameters showed dose-proportionality with a short terminal half-life of approximately 2 hours.”
Raun et al., Eur J Endocrinol, 1998
“Ipamorelin displayed high GH-releasing potency and efficacy in vitro and in vivo without releasing ACTH or cortisol.”

Last verified: May 3, 2026

Reconstitution calculator

For research purposes only. Not for human consumption. Always verify calculations independently.

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How reconstitution works · Understanding syringe units

Cost-per-dose recalculates as you adjust the calculator above.

§ Frequently asked

Common questions about Ipamorelin

What is ipamorelin?: Ipamorelin is a synthetic pentapeptide ghrelin-receptor agonist that selectively stimulates GH release without the substantial cortisol or prolactin elevations associated with older ghrelin-mimetic compounds like GHRP-2 and GHRP-6.
Is ipamorelin FDA-approved?: No. Ipamorelin is not approved by the FDA, MHRA, Health Canada, or the TGA for any indication. Research-peptide vendors sell it for laboratory research only.
What is the half-life of ipamorelin?: Published pharmacokinetic studies report a half-life of approximately 2 hours after subcutaneous administration, which supports the multi-times-per-day dosing patterns used in published research protocols.
What dose of ipamorelin is used in research?: Doses reported in published preclinical and early human studies vary by endpoint. Pepticker does not publish a dosing protocol — refer to the original literature for the specific study you are reproducing.
What is ipamorelin commonly stacked with?: The most widely discussed stack is ipamorelin plus CJC-1295 (with or without DAC) — pairing the ghrelin-arm and GHRH-arm of GH secretion in research protocols.
Is ipamorelin legal?: Ipamorelin is sold for research use in the US, Canada, and the UK. In Australia it is TGA Schedule 4 and personal import is tightly controlled. Status is informational — not legal advice.

Editorial summary of published research. Not medical advice. See /methodology for sourcing.

Research use only. The compounds listed on this page are not approved for human use through research-chemical channels. Nothing on this page is medical advice. Consult a qualified clinician before considering any peptide protocol. See affiliate disclosure and our scoring methodology.

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