Pepticker
Curated Stack

GLP-1 Comparison: Tirzepatide vs Semaglutide

TirzepatideSemaglutide

Editorial review by Pepticker Editorial· Pepticker editorial team

Published May 4, 2026

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Protocol rationale
Tirzepatide
Tirzepatide
In the SURMOUNT-1 Phase 3 trial, Tirzepatide (dual GIP/GLP-1 agonist) showed mean body weight reductions of approximately 20–22% at 72 weeks (Source: Jastreboff et al. 2022) — the highest reported efficacy in its class to date. Published protocols started at 2.5 mg/wk and titrated every 4 weeks. NOTE: This is an educational comparison stack — do NOT combine tirzepatide and semaglutide simultaneously.
2.5 mg/wk · 12 weeks
Semaglutide
Semaglutide
In the STEP-1 Phase 3 trial, Semaglutide (selective GLP-1 agonist) showed mean body weight reductions of approximately 14.9% at 68 weeks (Source: Wilding et al. 2021). Published protocols used once-weekly subcutaneous dosing starting at 0.25 mg/wk titrated over 16–20 weeks. Compare cost per dose against Tirzepatide for cost-of-research analysis. Do not combine with Tirzepatide.
0.25 mg/wk · 12 weeks
Interactive cost planner

Doses pre-filled from the editorial protocol. Adjust quantities and durations — costs and vendor recommendations update live.

1 — Select peptides (2–5)
Tirzepatide
metabolic
total mg
30.0
Semaglutide
metabolic
total mg
3.0
+201 more — refine your search
Share this stack with pre-filled doses
Interaction notes
Conflict

Multiple GLP-1 agonists (tirzepatide, semaglutide) are stacked. These act on overlapping receptors — running more than one simultaneously is not standard research practice and may compound adverse effects.

tirzepatidesemaglutide
2 — Cost analysis
Split purchaseCheapest
$101.00

Best vendor per peptide individually

Single vendor
$101.00

Best all-in-one: RetaOneLabs

Split purchase saves $0.00 vs. single vendor — but requires 1 separate orders.

Dosing logistics
Total vials
4
tirzepatide: 3× 10mg
semaglutide: 1× 10mg
BAC water vials
1

30 mL / 2 mL per recon

Syringes
84

7 inj/wk × longest protocol

3 — Purchase plan

Cheapest option per peptide at your specified quantities. Affiliate links apply.

tirzepatide
3× 10mg vials from RetaOneLabs
$2.400/mg
$72.00
Buy →
semaglutide
1× 10mg vials from RetaOneLabs
$2.900/mg
$29.00
Buy →
4 — Vendor coverage

Expand to see which vendors carry which peptides in this stack.

Research purposes only. Pepticker is an editorial price comparator, not a clinical adviser. Prices are approximate and subject to change. Verify independently before any use. All vendors sell peptides for research only and not for human consumption.

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