Pepticker
Live
BPC-157 $2.80/mg— flat|Tirzepatide $2.08/mg— flat|Semaglutide $1.95/mg— flat|Retatrutide $2.90/mg— flat|TB-500 $3.50/mg— flat|MOTS-C $2.48/mg— flat|GHK-Cu $0.27/mg— flat|Cagrilintide $8.80/mg— flat|BPC-157 $2.80/mg— flat|Tirzepatide $2.08/mg— flat|Semaglutide $1.95/mg— flat|Retatrutide $2.90/mg— flat|TB-500 $3.50/mg— flat|MOTS-C $2.48/mg— flat|GHK-Cu $0.27/mg— flat|Cagrilintide $8.80/mg— flat|
Curated Stack

GLP-1 Comparison: Tirzepatide vs Semaglutide

tirzepatidesemaglutide

Editorial review by Pepticker Editorial· Pepticker editorial team

Published May 4, 2026

Protocol rationale
tirzepatide
Tirzepatide
Tirzepatide (dual GIP/GLP-1 agonist) shows 20–22% mean body weight reduction at 72 weeks in the SURMOUNT Phase 3 trials — the highest efficacy in its class. Research protocols start at 2.5 mg/wk and titrate every 4 weeks. NOTE: This is an educational comparison stack — do NOT combine tirzepatide and semaglutide simultaneously.
2.5 mg/wk · 12 weeks
semaglutide
Semaglutide
Semaglutide (selective GLP-1 agonist) is the most widely studied GLP-1 receptor agonist, with 14–15% mean body weight reduction in the STEP trials. Once-weekly subcutaneous dosing starting at 0.25 mg/wk titrated over 16–20 weeks. Compare cost per dose against Tirzepatide to determine which is more economical at your target dose. Do not combine with Tirzepatide.
0.25 mg/wk · 12 weeks
Interactive cost planner

Doses pre-filled from the editorial protocol. Adjust quantities and durations — costs and vendor recommendations update live.

1 — Select peptides (2–5)
Tirzepatide
metabolic
total mg
30.0
Semaglutide
metabolic
total mg
3.0
+200 more — refine your search
Share this stack with pre-filled doses
Interaction notes
Conflict

Multiple GLP-1 agonists (tirzepatide, semaglutide) are stacked. These act on overlapping receptors — running more than one simultaneously is not standard research practice and may compound adverse effects.

tirzepatidesemaglutide
2 — Cost analysis
Split purchaseCheapest
$101.00

Best vendor per peptide individually

Single vendor
$101.00

Best all-in-one: RetaOneLabs

Split purchase saves $0.00 vs. single vendor — but requires 1 separate orders.

Dosing logistics
Total vials
4
tirzepatide: 3× 10mg
semaglutide: 1× 10mg
BAC water vials
1

30 mL / 2 mL per recon

Syringes
84

7 inj/wk × longest protocol

3 — Purchase plan

Cheapest option per peptide at your specified quantities. Affiliate links apply.

tirzepatide
3× 10mg vials from RetaOneLabs
$2.400/mg
$72.00
Buy →
semaglutide
1× 10mg vials from RetaOneLabs
$2.900/mg
$29.00
Buy →
4 — Vendor coverage

Expand to see which vendors carry which peptides in this stack.

Research purposes only. Pepticker is an editorial price comparator, not a clinical adviser. Prices are approximate and subject to change. Verify independently before any use. All vendors sell peptides for research only and not for human consumption.

Back to all curated stacks